The Taoiseach Simon Harris will meet with Spanish Prime Minister Pedro Sánchez at Government Buildings this afternoon.
It will mark the second time this week that the leaders have held discussions.
The pair had met yesterday in Warsaw, at a summit hosted by Polish Prime Minister Donald Tusk.
At the event, Mr Harris said there was not likely to be an EU-wide approach to recognising the state of Palestine.
The Taoiseach said Ireland would proceed to recognise Palestine with a group of member states, although it was not clear how many that would be.
Efforts by both Spain and Ireland to recognise the State of Palestine is expected to top the agenda in the bilateral meeting later today.
Both countries have also requested that the European Commission review whether Israel is complying with its human rights obligations under the EU/Israel Association Agreement.
